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Title: "Single T Cell Recognition and Signaling"

In this talk, Jun Huang will present the recent progresses of his laboratory in T-cell and CAR T-cell detection and profiling, PD-1–mediated inhibition in T cells, T cell receptor bond conformations, and 4D spatiotemporal omics of T cell receptors at the live T cell membrane. He will also briefly introduce other research projects of his laboratory.

Jun Huang is an assistant professor at the Pritzker School of Molecular Engineering, Committee on Cancer Biology, Committee on Immunology, and the Graduate Program in Biophysical Sciences of the University of Chicago. He received his PhD in Bioengineering from Georgia Institute of Technology where he worked with Prof. Cheng Zhu to measure the in situ binding kinetics of T cell receptors. As a postdoctoral fellow working with Prof. Mark Davis at Stanford University, he developed a single-molecule imaging method to quantify T cell sensitivity.

His lab performs basic and translational research with the objective of developing effective vaccines and cell immunotherapies for the treatment of cancer, infection, and autoimmunity. He carries out basic immunological research, focusing on molecular mechanisms of T cell recognition and signaling at the single-molecule level. He performs systems immunology, studying the development, differentiation, and metabolism of T cells at the single-cell level. He engineers CAR-T cells, aiming at the treatment of cancer and autoimmunity. He develops new biomaterials, enabling the detection, profiling, and manipulation of T cells and other immune cells for diagnosis and treatment. He is a recipient of the NSF Career Award, the NIH Director's New Innovator Award, the Cancer Research Foundation Young Investigator Award, and the NIH Pathway to Independence Award.

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