ETS-ACS S.C. Lind Lecture
Dr. Michael Klein
Dean, College of Science and Technology
Laura H. Carnell Professor of Science
Host: Dr. John Larese, Chemistry Professor
Membrane-bound channel proteins play a key role in human physiology. The transient receptor potential (TRP) family have an overall architecture similar to K+ and Na+ voltage gated cationic channels, which are responsible for the action potential, and consist of four sensor domains linked to a central pore. Structural studies over the past decade or so have yielded clues into the possible operational mechanisms of the TRP nanomachines, including the so-called capsaicin or vanilloid receptor, TRPV1. This presentation is focused on TRPV1, which promotes cation currents across cellular membranes in response to stimuli such as hotness, acidity and voltage. The molecular underpinnings of TRPV1 function, in particular the mechanism of temperature sensitivity, are still largely unknown. Molecular simulations have been employed in an attempt to shed light on the mechanism of the closed to open transition of TRPV1 in an attempt to rationalize experimental observations on this important sensing machine.
Wednesday, November 14, 2018 at 5:00pm
Strong Hall , 101 1621 Cumberland Ave.