Fall Chem501 Seminar
UT Host: Dr. Chris Baker
Speaker: Dr. Mark Hayes
Professor, Honors Professor
School of Molecular Sciences
Arizona State University
Title: “High Resolution Interfacial Separations for Cells, Bioparticles and Molecules”
Very high resolution separations for cells, bioparticles (viruses, exosomes, vesicles, organelles, etc.) and proteins are possible by using new thoughtfully shaped flow and electric fields. This is a result of an ability to induce large fields and gradients on short length-scale systems that are controlled with great precision. On various two-dimensional systems, we have shown efficient separations for biomolecules, bioparticles (viruses, vesicles) and cells, along with a foundational theory consistent with these results. These structures can also be placed in parallel and/or in series allowing multistep dynamic processing for extremely refined separations. I will be presenting data on planar systems which demonstrate the capabilities and show the foundational separations, including proteins, viruses, and vesicles, and a strain-specific pathogen identification system. Specific experimental results will be presented showing susceptible versus antibiotic resistant bacteria separations for unlabeled cells, protein separations and isolation and concentration of vesicle populations. While these are wide ranging applications, there is an underlying structure to the separation mechanisms. Forward-looking arguments will be discussed in terms of impact of three-dimensional systems, massively parallel and dynamical systems and their applications. These capabilities will enable new analytical and process capabilities across many industries and applications.
Mark A. Hayes is a professor in the School of Molecular Science (formerly the Department of Chemistry and Biochemistry) at Arizona State University, where his research centers on exploiting gradients in novel configurations for separations. His academic career has produced significant results across several disciplines within the analytical and physical chemistry community that includes aspects of engineering, physics, biology and medicine. He initially worked in private industry at a ‘mom & pop’ analytical laboratory and at J&W Scientific capillary gas chromatography column manufacturer (now part of Agilent) after earning his undergraduate degree at Humboldt State University (California). He then entered graduate school at Penn State University and studied under Professor Andrew G. Ewing, developing electroosmotic flow control mechanisms. Postdoctoral studies were with Dr. Werner Kuhr at the University of California, Riverside focused on electrochemical probes. He currently holds the W. W. Clyde Visiting Chair at University of Utah and is the recipient of the A.A. Benedetti-Pichler and FACSS Distinguished Service Awards, and was a finalist for the SciX Conference Innovation Award. He is has served as Program, Governing Board, Long Range Planning and Marketing Chair for FACSS, Councilor, Vice-President and President of the AES Electrophoresis Society, and is currently the Chair of the SubDivision on Chromatography and Separations Chemistry for the ACS Analytical Division. He has mentored fifty undergraduate and graduate students, producing eighteen doctorates, supporting them towards prestigious fellowships (NSF, Kirkbright, ACS, Fulbright, FLAS and local awards).
Thursday, September 19 at 3:45pm to 5:00pm
Buehler Hall, 555
1420 Circle Drive, Knoxville, TN 37996