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Spring Chemistry 501 Seminar

UT Host: Dr. David Jenkins

Speaker: Dr. Cathleen Crudden

A.V. Douglas Distinguished Professor of Chemistry and Canada Research Chair

Queen's University-Kingston Ontario

Title: "Metal catalysts, clusters and surfaces: Catalytic preparation of chiral bio-molecules and the chemistry of carbon-based monolayers"

Abstract:   The use of N-heterocyclic carbenes to modify homogeneous metal catalysts is widespread since the high metal–NHC bond strength renders high oxidative and chemical stability to NHC–ligated metal complexes. Despite this fact, the use of NHCs to modify metal surfaces is virtually unprecedented.

We will describe the first example of the synthesis of gold surfaces, including Au(111), Au nanoparticles and Au nanoclusters.  Films prepared by the deposition of NHCs show molecular ordering on the surface and remarkable stability. The impact of this stability on the chemistry of nanoclusters will also be discussed.

We will also describe advances in organoboron chemistry that have dramatically broadened the applicability of this versatile element. In particular, we will describe its application in the preparation of complex chiral molecules of interest to the pharmaceutical industry and the ability to cross-couple seemingly identical boron substituents with different aryliodides. The development of novel electrophiles for Suzuki-Miyaura cross coupling chemistry in the preparation of bioactive molecules will also be presented as will our developments in the use of sulfones as electrophiles for cross-coupling reactions.

Bio:  Cathleen Crudden was born in Belfast, N. Ireland, and raised in Toronto, Canada. She obtained B.Sc. and M.Sc. degrees at the University of Toronto under Professor Mark Lautens. Her Ph.D. was carried out with Professor Howard Alper, followed by an NSERC postdoctoral fellowship with Professor Scott Denmark at the University of Illinois Urbana Champaign. During her Ph.D., she also worked in the labs of Shinji Murai at Osaka University.

Cathleen is currently A.V. Douglas Distinguished Professor of Chemistry and Canada Research Chair (Tier 1) at Queen’s University in Kingston, Ontario. She also holds a Research Professorship and runs a satellite lab at the Institute of Transformative Bio-Molecules (ITbM) in Nagoya, Japan. Cathleen has won numerous research awards including the 2019 Cope Scholar award of the American Chemical Society, 2018 Canadian Catalysis Society Award, the 2018 Carol Taylor award from the International Precious Metals Institute, the 2017 R. U. Lemieux award and the 2011 Clara Benson award, both of the Canadian Chemical Society.

Since her time as a student, Cathleen has maintained close ties to Japan, having been a visiting professor in the labs of Professor Ryoji Noyori (Nobel Prize 2001) and a Global Center of Excellence Professor at Kyoto University. She has held visiting Professorships in Spain and France.  She is Associate Editor for ACS Catalysis and is a member of the Board of Editors for Organic Syntheses. She sits on the editorial advisory boards of several American, German and Japanese journals. She served as President of the Canadian Society for Chemistry in 2012/2013 and on the Board of Directors for two terms representing the Catalysis Division. She is currently chair of the NSERC–Chemistry Liaison Panel.

Trained as a catalysis chemist, Cathleen has recently established herself in materials chemistry. Her recent work identifying a new class of carbon-based SAMs has been called "game changing" and "the new gold standard" by international experts. She and her group have demonstrated that N-heterocyclic carbenes are a viable alternative to thiols, providing a novel method for the modification of metal surfaces with organic ligands, an approach that works with a variety of metals on planar and curved surfaces. In addition, she has made seminal impacts on the generation of chiral compounds using cross-coupling approaches, and is continuing to push boundaries in the development of novel electrophiles for cross-coupling chemistry.  

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Thursday, April 22 at 4:30pm to 5:30pm

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Linda Sherman

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